NIAD-4

Names

[ Name ]:
NIAD-4

[Synonym ]:
Propanedinitrile,[[5'-(4-hydroxyphenyl)[2,2'-bithiophen]-5-yl]methylene]
[[5-(4-Hydroxyphenyl)[2,2-bithiophen]-5-yl]methylene]-propanedinitrile
NIAD-4
2-[[5'-(4-Hydroxyphenyl)[2,2'-bithiophen]-5-yl]methylene]propanedinitrile

Biological Activity

[Description]:

NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Kenneth T. Cheng, et al. [[5'-(4-Hydroxyphenyl)[2,2’-bithiophen]-5-yl]methylene]-propanedinitrile NIAD-4.

Chemical & Physical Properties

[ Density]:
1.385±0.06 g/cm3

[ Molecular Formula ]:
C₁₈H₁₀N₂OS₂

[ Molecular Weight ]:
334.41500

[ Exact Mass ]:
334.02300

[ PSA ]:
124.29000

[ LogP ]:
5.27976

[ Water Solubility ]:
Insuluble (1.6E-3 g/L) (25 ºC)

Related Compounds

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