ERAP1-IN-1

Names

[ Name ]:
ERAP1-IN-1

Biological Activity

[Description]:

ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

ERAP1[1]

[In Vitro]

ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substratesv[1]. ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context[1].

[References]

[1]. Maben Z, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2019 Dec 30.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁F₃N₂O₅S

[ Molecular Weight ]:
458.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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