EACC

Names

[ Name ]:
EACC

Biological Activity

[Description]:

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

[Target]

Autophagy[1]

[In Vitro]

EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function[1]. EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes[1]. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17[1].

[References]

[1]. Vats S, et al. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Mol Biol Cell. 2019 Aug 1;30(17):2283-2295.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁N₃O₆S₂

[ Molecular Weight ]:
369.37

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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