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Gsk466317a

Names

[ CAS No. ]:
864082-48-4

[ Name ]:
Gsk466317a

Biological Activity

[Description]:

GSK466317A is a PKA inhibitor, with an IC50 of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC50s of 1000, 31.62, and 39.81 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA
Signaling Pathways >> Stem Cell/Wnt >> PKA
Research Areas >> Neurological Disease

[Target]

PKA:12.59 μM (IC50)


[References]

[1]. Homan KT, et, al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H16ClF3N4O2

[ Molecular Weight ]:
448.83

Related Compounds