N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYCYTIDINE

Names

[ Name ]:
N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYCYTIDINE

[Synonym ]:
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-deoxycytidine
N4-benzoyl-5'-O-dimethoxytrityl-3'-deoxycytidine
N4-Benzoyl-3A'A inverted exclamation markA'A-deoxy-5A'A inverted exclamation markA'A-O-DMT-D-cytidine
N4-benzoyl-5'-O-dimethoxytrityl-3'-deoxyribicytidine
Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-
N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine

Biological Activity

[Description]:

N4-Benzoyl-5’-O-(4,4-dimethoxytrityl)-3’-deoxy cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₇H₃₅N₃O₇

[ Molecular Weight ]:
633.69

[ Exact Mass ]:
633.247498

[ PSA ]:
121.14000

[ LogP ]:
6.22

[ Index of Refraction ]:
1.626

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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