11β-HSD1-IN-11

Names

[ CAS No. ]:
859721-81-6

[ Name ]:
11β-HSD1-IN-11

Biological Activity

[Description]:

11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[Target]

IC50: 0.13 μM (Rat 11β-HSD1), 0.34 μM (Human 11β-HSD1)[1]


[In Vivo]

A single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C15H11F3O3S

[ Molecular Weight ]:
328.31

Related Compounds