[Glu2]-TRH

Names

[ Name ]:
[Glu2]-TRH

[Synonym ]:
GLP-GLU-PRO-NH2
PE-E-P-NH2
fertilization promoting peptide
FPP
(GLU2)-TRH
PYR-GLU-PRO-NH2
PGLU-GLU-PRO AMIDE
PYROGLU-GLU-PRO AMIDE
FPP,Fertilization-ProMoting Peptide
pyroglutamyl-glutamyl-prolineamide

Biological Activity

[Description]:

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].

[Related Catalog]:

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Research Areas >> Neurological Disease

[In Vivo]

(Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用[1]。 (Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体治疗组相比，睡眠时间减少了大约 20%[1]。 Animal Model: Male Swiss-Webster mice (30 g)[1] Dosage: 1, 2, 5, 10, 15, 25, 50, 100 μmol/kg Administration: IV; 10 min before Pentobarbital (60 mg/kg, i.p.) Result: Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.

[References]

[1]. Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.

Chemical & Physical Properties

[ Density]:
1.416g/cm3

[ Boiling Point ]:
899.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₂N₄O₆

[ Molecular Weight ]:
354.35800

[ Flash Point ]:
498ºC

[ Exact Mass ]:
354.15400

[ PSA ]:
158.90000

[ Index of Refraction ]:
1.575

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Fertilization promoting peptide--a possible regulator of sperm function in vivo.

Vitam. Horm. 63 , 1-28, (2001)

Fertilization promoting peptide (FPP), a tripeptide related to thyrotrophin releasing hormone (TRH), is found in seminal plasma. Recent evidence obtained in vitro suggests that FPP may play an importa...

Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner.

Mol. Reprod. Dev. 57(4) , 384-92, (2000)

Fertilization promoting peptide (FPP) and adenosine have been shown to act as first messengers, regulating availability of the second messenger cAMP by initially stimulating cAMP production in uncapac...

In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).

Peptides 22(12) , 2091-7, (2001)

EEP is a tripeptide structurally similar to thyrotropin releasing hormone (TRH) and, like TRH, it is found in the mammalian brain. TRH has been found to increase in brain regions after seizures and to...

Related Compounds

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