RSV L-protein-IN-5

Names

[ CAS No. ]:
851658-28-1

[ Name ]:
RSV L-protein-IN-5

Biological Activity

[Description]:

RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> RSV

[Target]

EC50: 0.1 μM ()[1]


[References]

[1]. Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H36N6O4

[ Molecular Weight ]:
556.66

Related Compounds

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