Coenzyme A

Names

[ CAS No. ]:
85-61-0

[ Name ]:
Coenzyme A

[Synonym ]:
Coalip
COA-SH
coenzyme-A
EINECS 201-619-0
CoASH
Lucina
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate
CoA
Thiol-CoA
co-enzyme-A
MFCD06795839
HSCoA
HS-CoA
CONENZYME A
Coenzyme A
Aluzime
Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate)
Coenzym A

Biological Activity

[Description]:

Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Baković J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
146 - 147

[ Melting Point ]:
-5ºC

[ Molecular Formula ]:
C₂₁H₃₆N₇O₁₆P₃S

[ Molecular Weight ]:
767.534

[ Exact Mass ]:
767.115234

[ PSA ]:
414.79000

[ LogP ]:
-4.02

[ Index of Refraction ]:
1.737

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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