AP102

Names

[ Name ]:
AP102

Biological Activity

[Description]:

AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

SSTR2:0.63 nM (IC50)

SSTR5:0.65 nM (IC50)

[References]

[1]. Tarasco E, et al. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine. 2017 Oct;58(1):124-133.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₆₆I₂N₁₂O₁₀S₂

[ Molecular Weight ]:
1313.07

Related Compounds

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