Cyclosomatostatin

Names

[ Name ]:
Cyclosomatostatin

[Synonym ]:
Cyclosomatostatin
C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR: BZL]
6-(4-aminobutyl)-12-benzyl-9-(1H-indol-3-ylmethyl)-3-(1-phenylmethoxyethyl)-1,4,7,10,13-pentazacycloicosane-2,5,8,11,14-pentone
Cyclo(7-Aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])

Biological Activity

[Description]:

Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

[References]

[1]. Shirin R Modarai, et al. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. BMC Cancer. 2016 Dec 7;16(1):941.

Chemical & Physical Properties

[ Density]:
1.147g/cm3

[ Boiling Point ]:
1118.4ºC at 760 mmHg

[ Molecular Formula ]:
C₄₄H₅₇N₇O₆

[ Molecular Weight ]:
779.96700

[ Flash Point ]:
630.2ºC

[ Exact Mass ]:
779.43700

[ PSA ]:
196.54000

[ LogP ]:
6.05120

[ Index of Refraction ]:
1.558

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

J. Neurosci. 34(35) , 11769-80, (2014)

Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...

Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.

Korean J. Physiol. Pharmacol. 12(5) , 253-8, (2008)

Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nocice...

Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine.

Pharmacol. Res. 95-96 , 71-81, (2015)

Curcumin (CUR) has been proven to be clinically effective in rheumatoid arthritis (RA) therapy, but its low oral bioavailability eclipses existent evidence that attempts to explain the underlying mech...