<Suppliers Price>

SOD1-Derlin-1 inhibitor-1

Names

[ CAS No. ]:
840461-03-2

[ Name ]:
SOD1-Derlin-1 inhibitor-1

Biological Activity

[Description]:

SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

IC50: 7.11 μM (SOD1G93A-Derlin-1 complex)[1]


[In Vitro]

SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM[1]. SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM[1].

[References]

[1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H12Br2N4OS

[ Molecular Weight ]:
504.20

Related Compounds