WIKI4

Names

[ Name ]:
WIKI4

[Synonym ]:
2-(3-{[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-
wiki4

Biological Activity

[Description]:

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> β-catenin

Research Areas >> Cancer

[References]

[1]. James RG, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/?-catenin signaling. PLoS One. 2012;7(12):e50457.

[Related Small Molecules]

XAV-939 | Salinomycin | Berberine chloride hydrate | KYA 1797K | FH535 | SKL2001 | LF3 | WAY-262611 | PNU 74654 | KY1220 | Pamidronic acid | Cardiogenol C (hydrochloride) | Nefopam hydrochloride | Triptonide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
783.1±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₂₃N₅O₃S

[ Molecular Weight ]:
521.590

[ Flash Point ]:
427.4±35.7 °C

[ Exact Mass ]:
521.152161

[ PSA ]:
117.20000

[ LogP ]:
5.20

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.716

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport