2'-Fluoro-5-ethylarabinosyluracil

Names

[ Name ]:
2'-Fluoro-5-ethylarabinosyluracil

[Synonym ]:
1-[5-(2-Fluoroethyl)-D-arabinopyranosyl]-2,4(1H,3H)-pyrimidinedione
FEAU
1-Dfafeu
1-(2-Deoxy-2-fluoroarabinofuranosyl)-5-ethyluracil
1-[(3S,4R,5S)-6-(2-Fluoroethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-[(5ξ)-6,7-dideoxy-7-fluoro-D-arabino-heptopyranosyl]-
1-[(5ξ)-6,7-Dideoxy-7-fluoro-D-arabino-heptopyranosyl]-2,4(1H,3H)-pyrimidinedione
2'-Fluoro-5-ethylarabinosyluracil
1-[(5ξ)-6,7-Dideoxy-7-fluoro-D-arabino-heptopyranosyl]pyrimidine-2,4(1H,3H)-dione

Biological Activity

[Description]:

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₁₅FN₂O₅

[ Molecular Weight ]:
274.25

[ Exact Mass ]:
290.091400

[ PSA ]:
124.78000

[ LogP ]:
-0.88

[ Index of Refraction ]:
1.587

2'-Fluoro-5-ethylarabinosyluracil

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds