Levonordefrin；Corbadrine

Names

[ CAS No. ]:
829-74-3

[ Name ]:
Levonordefrin；Corbadrine

[Synonym ]:
4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
LEVONORDEFRIN
1(S),2(R)-(+)-nordefrin
MFCD00134415
(-)-Nordefrin
Neo-cobefrin
Levonordefrin Base
Levonordefrin (200 mg)
D-(-)-Cobefrin
l-Cobefrin
BA 2818
CORBADRINE

Biological Activity

[Description]:

Levonordefrin, a common alternative to levoepinephrine as a vasoconstrictor in dental local anesthetic preparations, is usually used in fivefold higher concentrations. Levonordefrin is generally considered equivalent to epinephrine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Robertson VJ, et al. Quantitative and qualitative analysis of the pressor effects of levonordefrin.

Chemical & Physical Properties

[ Density]:
1.328g/cm3

[ Boiling Point ]:
431.575ºC at 760 mmHg

[ Melting Point ]:
212-215ºC dec.

[ Molecular Formula ]:
C₉H₁₃NO₃

[ Molecular Weight ]:
183.20

[ Flash Point ]:
214.809ºC

[ Exact Mass ]:
183.09000

[ PSA ]:
86.71000

[ LogP ]:
1.17870

[ Index of Refraction ]:
1.633

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330-P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1 / PGII

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%