A 784168

Names

[ Name ]:
A 784168

Biological Activity

[Description]:

A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[References]

[1]. Cui M, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci. 2006;26(37):9385-9393.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅F₆N₃O₃S

[ Molecular Weight ]:
479.39600

[ Exact Mass ]:
479.07400

[ PSA ]:
87.75000

[ LogP ]:
5.38790

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.