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A-943931 dihydrochloride

Names

[ CAS No. ]:
1227675-50-4

[ Name ]:
A-943931 dihydrochloride

[Synonym ]:
5H-Benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6,7-dihydro-, hydrochloride (1:2)
4-[(3R)-3-Amino-1-pyrrolidinyl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine dihydrochloride
4-[(3R)-3-Aminopyrrolidin-1-yl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine dihydrochloride

Biological Activity

[Description]:

A-943931 (Compound 10) is a histamine H4 receptor antagonists. A-943931 has improved pharmacotropic and in vivo efficacy in models of pain and inflammation. A-943931 can be used in vivo anti-inflammatory and anti-nociception research [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Cowart MD, et al. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J Med Chem. 2008 Oct 23;51(20):6547-57.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H23Cl2N5

[ Molecular Weight ]:
368.304

[ Exact Mass ]:
367.133057

Related Compounds