Bis(2-Chloroethyl)amine hydrochloride
Names
[ CAS No. ]:
821-48-7
[ Name ]:
Bis(2-Chloroethyl)amine hydrochloride
[Synonym ]:
2-Chlor-N-(2-chlorethyl)ethanaminhydrochlorid
MFCD00012515
2-Chloro-N-(2-chloroethyl)ethanamine hydrochloride (1:1)
Bis(2-chloroethyl)amine Hydrochloride
EINECS 212-479-5
2-chloro-N-(2-chloroethyl)ethanamine hydrochloride
Ethanamine, 2-chloro-N- (2-chloroethyl)-, hydrochloride
Bis(β-chloroethyl)amine hydrochloride
Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1)
Bis(2-Chloroethyl)Amine HCL
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
1.125 g/cm3
[ Boiling Point ]:
204.2ºC at 760 mmHg
[ Melting Point ]:
212-214 °C(lit.)
[ Molecular Formula ]:
C4H10Cl3N
[ Molecular Weight ]:
178.49
[ Flash Point ]:
77.3ºC
[ Exact Mass ]:
176.987885
[ PSA ]:
12.03000
[ LogP ]:
2.24650
[ Water Solubility ]:
SOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- IA1225000
- CHEMICAL NAME :
- Diethylamine, 2,2'-dichloro-, hydrochloride
- CAS REGISTRY NUMBER :
- 821-48-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C4-H9-Cl2-N.Cl-H
- MOLECULAR WEIGHT :
- 178.50
- WISWESSER LINE NOTATION :
- G2M2G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 mg/m3/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 170 umol/kg
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,1048,1973
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
IA1225000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29211980
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921199090
[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Toxicol. Ind. Health 11(1) , 89-97, (1995)
Nor-nitrogen mustard is an alkylating agent used in kilogram quantities in the production of various cytostatics. It has been shown to be mutagenic in vitro, and therefore must be regarded as a health...
Basic principles in preclinical cancer chemotherapy.J. Cancer Res. Clin. Oncol. 116(5) , 411-24, (1990)
Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.
Arch. Toxicol. 76(2) , 83-8, (2002)
Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adduc...