Sodium ionophore III

Names

[ Name ]:
Sodium ionophore III

[Synonym ]:
N,N,N',N'-Tetracyclohexyl-1,2-phenylenedioxydiacetamide
N,N-Dicyclohexyl-2-(2-[2-(dicyclohexylamino)-2-oxoethoxy]phenoxy)acetamide
ETH 2120
MFCD00077941
Sodium ionophore III
Acetamide,2,2'-[1,2-phenylenebis(oxy)]bis[N,N-dicyclohexyl

Biological Activity

[Description]:

Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Cardiovascular Disease

[In Vitro]

Preincubation of the cells with the Na+ ionophore sodium ionophore III not only stimulated caffeate reduction, but completely abolished ATP synthesis. Addition of sodium ionophore III to cells in the steady state of caffeate reduction immediately dissipated the intracellular ATP level[1]. Lactate-sulfate grown cells are insensitive to the Na+ ionophore, ETH2120[2]. Sodium ionophore III ligand is a very effective receptor for the Eu3+ and Am3+ cations and can be considered as a potential extraction agent for nuclear iste treatment[3].

[References]

[1]. Imkamp F, et al. Chemiosmotic energy conservation with Na(+) as the coupling ion during hydrogen-dependent caffeate reduction by Acetobacterium woodii. J Bacteriol. 2002 Apr;184(7):1947-51.

[2]. Wang L, et al. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ. 2016 Apr 14;4:e1919.

[3]. Makrlík, E, et al. Sodium Ionophore III as Very Effective Receptor for Trivalent Europium and Americium.J Solution Chem (2016) 45: 463.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
709.4ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₅₂N₂O₄

[ Molecular Weight ]:
552.78800

[ Flash Point ]:
382.8ºC

[ Exact Mass ]:
552.39300

[ PSA ]:
59.08000

[ LogP ]:
7.43220

[ Index of Refraction ]:
1.564

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H335

[ Precautionary Statements ]:
P261

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
37

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

T. Maruizumi et al.

Mikrochim. Acta I , 331, (1986)