Spergualin trihydrochloride

Names

[ Name ]:
Spergualin trihydrochloride

[Synonym ]:
Spergualin trihydrochloride

Biological Activity

[Description]:

Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Spergualin trihydrochloride derivatives likely acts as Hsp70 modulators[1].

[References]

[1]. Srikanth Patury, et al. Pharmacological Targeting of the Hsp70 Chaperone. Curr Top Med Chem. 2009;9(15):1337-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₄₀Cl₃N₇O₄

[ Molecular Weight ]:
512.90300

[ Exact Mass ]:
511.22100

[ PSA ]:
205.59000

[ LogP ]:
4.02890

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.

Bioorg. Med. Chem. Lett. 21(9) , 2587-90, (2011)

Spergualin is a natural product that exhibits immunosuppressive, anti-tumor and anti-bacterial activities. Its derivatives, such as 15-deoxyspergualin (15-DSG), have been clinically approved for acute...

Related Compounds

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