Tetramethylrhodamine-6-isothiocyanate

Names

[ Name ]:
Tetramethylrhodamine-6-isothiocyanate

[Synonym ]:
6-TRITC
T3163_SIAL
BIT3022
5(6)-Tetramethylrhodamine isothiocyanate
Tetramethylrhodamine-6-isothiocyanate
Tetramethylrhodamine isothiocyanate

Biological Activity

[Description]:

Tetramethylrhodamine-6-isothiocyanate is a potent fluorescent tracer. Tetramethylrhodamine-6-isothiocyanate can be used as an probe for haptenated proteins/peptides for the research of contact allergy. Tetramethylrhodamine-6-isothiocyanate can be used as a tracer for the confocal imaging in living cells[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Tetramethylrhodamine-6-isothiocyanate is relatively photostable and robust toward pH changes[1]. Tetramethylrhodamine-6-isothiocyanate as an extreme sensitizer induces a massive cell proliferation and gave an EC3 value of 0.92 mM (0.040%) in the murine LLNA (local lymph node assay)[1]. Tetramethylrhodamine-6-isothiocyanate (1.0 mg; 2h) can used as fluorescence probe for confocal imaging in Fe3O4@PDA incubated living cells[2].

[References]

[1]. Karlsson I, et al. Peptide Reactivity of Isothiocyanates--Implications for Skin Allergy. Sci Rep. 2016 Feb 17;6:21203.

[2]. Yue Q ,et al . A versatile ethanol-mediated polymerization of dopamine for efficient surface modification and the construction of functional core-shell nanostructures. J Mater Chem B. 2013 Nov 28;1(44):6085-6093.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₁N₃O₃S

[ Molecular Weight ]:
443.51800

[ Exact Mass ]:
443.13000

[ PSA ]:
104.20000

[ LogP ]:
4.76390

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn: Harmful;