Tetramethylrhodamine-5-isothiocyanate

Names

[ Name ]:
Tetramethylrhodamine-5-isothiocyanate

[Synonym ]:
Xanthylium
Tetramethylrhodamine-5-isothiocyanate
5-TRITC
5-TRITC,G isomer
MFCD00467978

Biological Activity

[Description]:

Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Alayed KM, et al. Immunostaining for rapid diagnosis of acute promyelocytic leukemia with the tetramethylrhodamine-5-isothiocyanate-conjugated anti-promyelocytic leukemia monoclonal antibody PG-M3. Arch Pathol Lab Med. 2013 Nov;137(11):1669-73.

[2]. Navarro SM, et al. Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days. Ther Deliv. 2014 Nov;5(11):1191-201.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₁N₃O₃S

[ Molecular Weight ]:
443.51800

[ Exact Mass ]:
443.13000

[ PSA ]:
104.20000

[ LogP ]:
4.76390

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Resolving the infection process reveals striking differences in the contribution of environment, genetics and phylogeny to host-parasite interactions.

BMC Biol. 9 , 11, (2011)

Infection processes consist of a sequence of steps, each critical for the interaction between host and parasite. Studies of host-parasite interactions rarely take into account the fact that different ...

Migratory properties of naive, effector, and memory CD8(+) T cells.

J. Exp. Med. 194 , 953-66, (2001)

It has been proposed that two different antigen-experienced T cell subsets may be distinguishable by their preferential ability to home to lymphoid organs (central memory cells) or nonlymphoid tissues...

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.

Br. J. Cancer 103 , 370-81, (2010)

Ewing's sarcoma family of tumours (ESFT) is a malignant small round-cell tumour of the bone and soft tissues. It is characterised by a strong tendency to invade and form metastases. The microenvironme...