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Pipequaline hydrochloride

Names

[ CAS No. ]:
80221-58-5

[ Name ]:
Pipequaline hydrochloride

[Synonym ]:
2-phenyl-4-(2-piperidin-4-ylethyl)quinoline hydrochloride
2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline monohydrochloride
Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl)-,monohydrochloride
2-Phenyl-4-(2-(4-piperidinyl)ethyl)quinoline monohydrochloride

Biological Activity

[Description]:

Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

Benzodiazepine receptor[1]


[References]

[1]. Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8.

[2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42.

Chemical & Physical Properties

[ Boiling Point ]:
489.2ºC at 760 mmHg

[ Molecular Formula ]:
C22H25ClN2

[ Molecular Weight ]:
352.90

[ Flash Point ]:
249.7ºC

[ Exact Mass ]:
352.17100

[ PSA ]:
24.92000

[ LogP ]:
5.96480

[ Storage condition ]:
-20°C

Related Compounds