AS 8351

Names

[ CAS No. ]:
796-42-9

[ Name ]:
AS 8351

[Synonym ]:
Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid]
2-hydroxy-1-napthaldehyde isonicotinoylhydrazone
2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone
1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid
isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide]
1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine
(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
AS-8351
AS8351

Biological Activity

[Description]:

AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Demethylase

Research Areas >> Cardiovascular Disease

[Target]

KDM5B[1]

[In Vitro]

AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2].

[References]

[1]. Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916.

[2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.364g/cm3

[ Boiling Point ]:
503.5ºC at 760 mmHg

[ Melting Point ]:
266 °C

[ Molecular Formula ]:
C₁₇H₁₃N₃O₂

[ Molecular Weight ]:
291.30400

[ Flash Point ]:
258.3ºC

[ Exact Mass ]:
291.10100

[ PSA ]:
74.58000

[ LogP ]:
3.09520

[ Index of Refraction ]:
1.715

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%