DC Chemicals Limited
China
Product Name: AS-8351
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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796-42-9

796-42-9 structure

796-42-9 structure

Name: AS 8351
Chemical Name: 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
CAS Number: 796-42-9
Molecular Formula: C₁₇H₁₃N₃O₂
Molecular Weight: 291.30400
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2017-04-11 04:09:03
Modify Date: 2024-01-04 17:04:53
AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

Name	2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
Synonyms	Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid] 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide] 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide AS-8351 AS8351

Description	AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Cardiovascular Disease
Target	KDM5B[1]
In Vitro	AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2].
References	[1]. Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916. [2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.

Density	1.364g/cm3
Boiling Point	503.5ºC at 760 mmHg
Melting Point	266 °C
Molecular Formula	C₁₇H₁₃N₃O₂
Molecular Weight	291.30400
Flash Point	258.3ºC
Exact Mass	291.10100
PSA	74.58000
LogP	3.09520
Index of Refraction	1.715

HS Code	2933399090

54-85-3 structure

54-85-3

708-06-5 structure

708-06-5

~75%

796-42-9 structure

796-42-9

Literature: Singh, Pramod Kumar; Kumar, Deo Nandan Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2006 , vol. 64, # 4 p. 853 - 858

Precursor 2
54-85-3 708-06-5
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%