GSK-J4
Names
[ CAS No. ]:
1373423-53-0
[ Name ]:
GSK-J4
[Synonym ]:
GSK-J4
Ethyl N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate
GSK J4 HCl
β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 8.6 µM (KDM6B), 6.6 µM (KDM6A)[5]
[In Vitro]
[In Vivo]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
581.2±50.0 °C at 760 mmHg
[ Molecular Formula ]:
C24H27N5O2
[ Molecular Weight ]:
417.504
[ Flash Point ]:
305.3±30.1 °C
[ Exact Mass ]:
417.216461
[ PSA ]:
80.24000
[ LogP ]:
3.75
[ Appearance of Characters ]:
white to beige
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.615
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble20mg/mL, clear
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
Articles
PLoS ONE 10 , e0141470, (2015)
To better understand how β-cells respond to proinflammatory cytokines we mapped the locations of histone 3 lysine 4 monomethylation (H3K4me1), a post-translational histone modification enriched at act...
New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.Hum. Mol. Genet. 23(24) , 6553-66, (2014)
Cardio-facio-cutaneous (CFC) syndrome is one of the 'RASopathies', a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS-MAPK pathway. Germline...
Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.PLoS ONE 10 , e0125626, (2015)
Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells. Histone 3 lysine 27 trimethylation...