Dichloroacetyl chloride
Names
[ CAS No. ]:
79-36-7
[ Name ]:
Dichloroacetyl chloride
[Synonym ]:
Acetyl chloride, 2,2-dichloro-
Dichloroacetyl chloride
2,2-Dichloroacetyl chloride
EINECS 201-199-9
MFCD00000840
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
107.5±0.0 °C at 760 mmHg
[ Melting Point ]:
< 25ºC
[ Molecular Formula ]:
C2HCl3O
[ Molecular Weight ]:
147.388
[ Flash Point ]:
31.8±22.3 °C
[ Exact Mass ]:
145.909302
[ PSA ]:
17.07000
[ LogP ]:
1.27
[ Vapour Pressure ]:
27.0±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.467
[ Stability ]:
Stable. Combustible. Incompatible with water, alcohols and oxidizing agents. Fumes in air.
[ Water Solubility ]:
MAY DECOMPOSE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AO6650000
- CHEMICAL NAME :
- Acetyl chloride, dichloro-
- CAS REGISTRY NUMBER :
- 79-36-7
- BEILSTEIN REFERENCE NO. :
- 1209426
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C2-H-Cl3-O
- MOLECULAR WEIGHT :
- 147.38
- WISWESSER LINE NOTATION :
- GYGVG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 650 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg/80W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 mg/plate
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19(Suppl 21),2,1992
Safety Information
[ Symbol ]:
GHS05, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314-H400
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R35;R50
[ Safety Phrases ]:
S9-S26-S45-S61
[ RIDADR ]:
UN 1765 8/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
AO6650000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Bioorg. Med. Chem. 16 , 5720-32, (2008)
The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...
Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.Toxicol. Appl. Pharmacol. 216(2) , 248-55, (2006)
Dichloroacetyl chloride (DCAC) is formed from trichloroethene (TCE), which is implicated in inducing/accelerating autoimmune response. Due to its potent acylating activity, DCAC may convert proteins t...
Photocatalysis of gaseous trichloroethylene (TCE) over TiO2: the effect of oxygen and relative humidity on the generation of dichloroacetyl chloride (DCAC) and phosgene.J. Hazard. Mater. 146(1-2) , 302-8, (2007)
Batch photocatalytic degradation of 80+/-2.5 ppm V trichloroethylene (TCE) was conducted to investigate the effect of the oxygen and relative humidity (RH) on the formation of the dichloroacetyl chlor...