Calmodulin antagonist-1

Names

[ Name ]:
Calmodulin antagonist-1

[Synonym ]:
1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1)
N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1)
N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride
N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride
OR0190T
Calmodulin antagonist-1

Biological Activity

[Description]:

Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Neuronal Signaling >> CaMK

[References]

[1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726.

Chemical & Physical Properties

[ Boiling Point ]:
501.5ºC at 760 mmHg

[ Melting Point ]:
243-246ºC

[ Molecular Formula ]:
C₁₄H₁₈Cl₂N₂O₂S

[ Molecular Weight ]:
349.28

[ Flash Point ]:
257.1ºC

[ Exact Mass ]:
348.046600

[ PSA ]:
80.57000

[ LogP ]:
5.48440

Safety Information

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

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