2-naphthol-d8

Names

[ Name ]:
2-naphthol-d8

[Synonym ]:
8-azabicyclo<5.4.0>undec-1(7)-en-9-one
1,3,4,5,6,7,8,O-octadeuterio-naphthalen-2-ol
1,2,3,4,5,6,7,8-Octahydrocyclohepta[b]pyrid-2-one
1,3,4,5,6,7,8,9-octahydro-cyclohepta[b]pyridin-2-one
2H-Cyclohepta[b]pyridin-2-one,1,3,4,5,6,7,8,9-octahydro
2-Oxo-1,2,3,4-tetrahydrocycloheptano<e>pyridin

Biological Activity

[Description]:

2-Naphthol-d8 is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Kapuci M, et al. Determination of cytotoxic and genotoxic effects of naphthalene, 1-naphthol and 2-naphthol on human lymphocyte culture. Toxicol Ind Health. 2014 Feb;30(1):82-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀D₈O

[ Molecular Weight ]:
152.21900

[ Exact Mass ]:
152.10800

[ PSA ]:
20.23000

[ LogP ]:
2.54540

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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