Blue FPG-A trisodium

Names

[ CAS No. ]:
78617-94-4

[ Name ]:
Blue FPG-A trisodium

Biological Activity

[Description]:

Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

p2x1 Receptor:35.5 μM (IC50)

P2Y1 Receptor:2.6 μM (IC50)


[In Vitro]

Blue FPG-A trisodium (RB 2 para) (1、3.2、10、32 和 100 μM) 抑制 α、β-亚甲基 ATP (α、β-MeATP) 诱导的大鼠输精管 (RVD) 收缩和 5’-o-(2-硫代二磷酸腺苷) (ADPβS) 诱导的卡巴胆碱 (Carbachol，HY-B1208) 预处理的豚鼠大肠带绦虫 (GPTC) 的松弛[1]。

[References]

[1]. Glänzel M, et al. Constitutional isomers of Reactive Blue 2 - selective P2Y-receptor antagonists? Eur J Med Chem. 2003 Mar;38(3):303-12.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H17ClN7Na3O11S3

[ Molecular Weight ]:
840.10

Related Compounds