M4 mAChR agonist-1

Names

[ CAS No. ]:
785705-53-5

[ Name ]:
M4 mAChR agonist-1

Biological Activity

[Description]:

M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

EC50: >10 μM (human M4)[1]

[References]

[1]. Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26(13):3029-3033.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈N₄OS

[ Molecular Weight ]:
290.38

Related Compounds

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