(±)-2-Butanol

Names

[ CAS No. ]:
78-92-2

[ Name ]:
(±)-2-Butanol

[Synonym ]:
(±)-2-butanol
DL-Butan-2-ol
1-methyl-1-propanol
DL-METHYLETHYLCARBINOL
2-Butanol, (±)-
butanol
dl-sec-Butanol
methyl-2-propanol
SEC-BUTYL ALCOHOL
3-Methylthiocrotonic acid,S-sec-butyl ester
sec-Butyl S-senecthioate
2-Butanol
Butan-2-ol
S-sec-Butyl 3-methyl-2-butenethioate
rac-2-butanol
EINECS 201-158-5
MFCD00004569
±-2-Butanol
sec-Butanol
sec-Butyl 3-methyl-2-butenethioate
Butyl alcohol, sec-

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
96.6±3.0 °C at 760 mmHg

[ Melting Point ]:
−115 °C(lit.)

[ Molecular Formula ]:
C₄H₁₀O

[ Molecular Weight ]:
74.122

[ Flash Point ]:
26.7±0.0 °C

[ Exact Mass ]:
74.073166

[ PSA ]:
20.23000

[ LogP ]:
0.69

[ Vapour density ]:
2.6 (vs air)

[ Vapour Pressure ]:
25.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.393

[ Stability ]:
Stable. Flammable. Substances to be avoided include acids, acid chlorides, acid anhydrides, oxidizing agents and halogens.

[ Water Solubility ]:
12.5 g/100 mL (20 ºc)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO1750000

CHEMICAL NAME :: sec-Butyl alcohol

CAS REGISTRY NUMBER :: 78-92-2

BEILSTEIN REFERENCE NO. :: 0773649

LAST UPDATED :: 199806

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C4-H10-O

MOLECULAR WEIGHT :: 74.14

WISWESSER LINE NOTATION :: QY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16000 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210) Volume(issue)/page/year: MSDS-5280-4

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 771 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,2,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 764 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,330,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4893 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Cardiac - pulse rate Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 41,31,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 277 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1067 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1218 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,296,1935 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 5000 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,469,1989

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 7000 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,469,1989 *** REVIEWS *** ACGIH TLV-TWA (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 150 ppm (450 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,32,1971 OSHA PEL (Gen Indu):8H TWA 150 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 150 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 150 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 150 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (305 mg/m3);STEL 150 ppm (455 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (303 mg/m3);STEL 150 ppm (455 mg/m3) JAN 1993 OEL-DENMARK:STEL 50 ppm (150 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 50 ppm (150 mg/m3);STEL 75 ppm (225 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-GERMANY:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-JAPAN:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 150 ppm (450 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 150 ppm (450 mg/m3) JAN 1993 OEL-RUSSIA:TWA 100 ppm;STEL 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 100 ppm (300 mg/m3);STEL 200 ppm (600 mg/m3) JAN 1993 OEL-TURKEY:TWA 150 ppm (450 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (300 mg/m3);STEL 150 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO sec-BUTYL ALCOHOL-air:10H TWA 100 ppm;STEL 150 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14410 No. of Facilities: 2929 (estimated) No. of Industries: 59 No. of Occupations: 47 No. of Employees: 42853 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14410 No. of Facilities: 5896 (estimated) No. of Industries: 97 No. of Occupations: 72 No. of Employees: 126196 (estimated) No. of Female Employees: 36723 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H319-H335-H336

[ Precautionary Statements ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R10;R36/37;R67

[ Safety Phrases ]:
S13-S24/25-S26-S46-S7/9

[ RIDADR ]:
UN 1120 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
EO1750000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2905142000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905142000

[ Summary ]:
HS: 2905142000. butan-2-ol. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tarrif:5.5%. general tariff:30.0%

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Related Compounds

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