b-Neo-Endorphin

Names

[ Name ]:
b-Neo-Endorphin

[Synonym ]:
L-Proline, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl-
L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl-L-proline
β-Neoendorphin
β-neo-endorphin
b-Neo-Endorphin

Biological Activity

[Description]:

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Research Areas >> Neurological Disease

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK1

ERK2

MMP-2

MMP-9

[In Vitro]

β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes[2]. β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes[2]. β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9[2]. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast[2]. Cell Viability Assay[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 20 h Result: Significantly increased the wound closure. Had no observable effect on cell viability. Western Blot Analysis[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 12 h Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₅₄H₇₇N₁₃O₁₂

[ Molecular Weight ]:
1100.27000

[ Exact Mass ]:
1099.58000

[ PSA ]:
418.21000

[ LogP ]:
1.59

[ Index of Refraction ]:
1.653

Related Compounds

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