Pentafluorophenol
Names
[ CAS No. ]:
771-61-9
[ Name ]:
Pentafluorophenol
[Synonym ]:
Pentaflurophenol
PENTAFLUORPHENOL
SM6680000 [RTECS]
QR BF CF DF EF FF
HOPFP
PERFLUOROPHENOL
2,3,4,5,6-Pentafluorophenol
pentafluoro-pheno
PFP-OH
Pentafluorophenol
pentafluoro-phenol
C6F5OH
EINECS 212-235-8
Phenol, pentafluoro-
PFP
Phenol, 2,3,4,5,6-pentafluoro-
2,3,4,5,6-pentafluoro-phenol
MFCD00002156
Sofosbuvir Impurity 29
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
146.3±35.0 °C at 760 mmHg
[ Melting Point ]:
34-36 °C(lit.)
[ Molecular Formula ]:
C6HF5O
[ Molecular Weight ]:
184.06
[ Flash Point ]:
72.2±0.0 °C
[ Exact Mass ]:
183.994751
[ PSA ]:
20.23000
[ LogP ]:
3.05
[ Vapour Pressure ]:
3.7±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.429
[ Storage condition ]:
Store in dark!
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, bases, acid chlorides, acid anhydrides.
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SM6680000
- CHEMICAL NAME :
- Phenol, pentafluoro-
- CAS REGISTRY NUMBER :
- 771-61-9
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C6-H-F5-O
- MOLECULAR WEIGHT :
- 184.07
- WISWESSER LINE NOTATION :
- QR BF CF DF EF FF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 322 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 283 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4108 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 90 (estimated) No. of Female Employees: 68 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Target Organs ]:
Blood, Central nervous system, Liver
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
C:Corrosive;Xi:Irritant;
[ Risk Phrases ]:
R20/21/22;R34;R36/37/38
[ Safety Phrases ]:
S26-S36-S45-S36/37/39-S36/37-S24/25-S23-S53
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
SM6680000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29081000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2908199090
[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%
Articles
Angew. Chem. Int. Ed. Engl. 45(16) , 2609-15, (2006)
Atmospheric pressure chemical ionization of fluorinated phenols in atmospheric pressure chemical ionization mass spectrometry, tandem mass spectrometry, and ion mobility spectrometry.
J. Am. Soc. Mass Spectrom. 10(11) , 1157-65, (1999)
Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) for fluorinated phenols (C6H5-xFxOH Where x = 0-5) in nitrogen with Cl- as the reagent ion yielded product ions of M Cl- through ...
Development and validation of a RP-HPLC method for the determination of gentamicin sulfate and its related substances in a pharmaceutical cream using a short pentafluorophenyl column and a charged aerosol detector.J. Pharm. Biomed. Anal. 51(3) , 521-31, (2010)
Gentamicin sulfate is a potent broad spectrum aminoglycoside antibiotic which is used as an active pharmaceutical ingredient (API) against both Gram-positive and Gram-negative bacteria. A reversed-pha...