Erythromycin Thicyanate

Names

[ Name ]:
Erythromycin Thicyanate

[Synonym ]:
ErythroMycin Thiocyanate CGMP
ErythroMicyn thiocyanate
ERYTHROMYCIN THIOCYANATE CP2000
erythromycin thiocynante
ERYTHROMYCIN THIOCYANATE NOT LESS THAN 750 U OF ERYFHROMYCIN PER MG
erythromycin A thiocyanate
ERYTHROMYCIN THIOCYNATE
erythromycin thiocyanante

Biological Activity

[Description]:

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Erythromycin inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively[1].

[References]

[1]. Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66(1):79-89.

[2]. Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006 Dec;100(3):185-91. Epub 2006 Nov 28.

Chemical & Physical Properties

[ Boiling Point ]:
818.4ºC at 760 mmHg

[ Molecular Formula ]:
C₃₈H₆₈N₂O₁₃S

[ Molecular Weight ]:
792.010

[ Flash Point ]:
448.8ºC

[ Exact Mass ]:
791.436951

[ PSA ]:
256.50000

[ LogP ]:
2.18288

Safety Information

[ HS Code ]:
2941500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2941500000