tert-butyl glycidyl ether
Names
[ CAS No. ]:
7665-72-7
[ Name ]:
tert-butyl glycidyl ether
[Synonym ]:
MFCD00010050
EINECS 231-640-0
tert-butyl glycidyl ether
Chemical & Physical Properties
[ Density]:
0.917 g/mL at 25 °C(lit.)
[ Boiling Point ]:
150-152 °C
[ Melting Point ]:
-70°C
[ Molecular Formula ]:
C7H14O2
[ Molecular Weight ]:
130.18500
[ Flash Point ]:
55°C
[ Exact Mass ]:
130.09900
[ PSA ]:
21.76000
[ LogP ]:
1.20030
[ Index of Refraction ]:
n20/D 1.417(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RR0475000
- CHEMICAL NAME :
- Oxirane, ((1,1-dimethylethoxy)methyl)-
- CAS REGISTRY NUMBER :
- 7665-72-7
- BEILSTEIN REFERENCE NO. :
- 0103483
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C7-H14-O2
- MOLECULAR WEIGHT :
- 130.21
- WISWESSER LINE NOTATION :
- T3OTJ B1OX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1000 ppm/6H/2W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 ppm/6H/2W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1000 ppm/6H/2W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 1250 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Skin;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5364 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 154 (estimated) No. of Female Employees: 3 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H302-H317-H319
[ Supplemental HS ]:
May form explosive peroxides.
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
10-19-22-36-43
[ Safety Phrases ]:
S16-S26-S36/37
[ RIDADR ]:
UN 3271 3/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
RR0475000
[ Packaging Group ]:
III
[ Hazard Class ]:
3.2
[ HS Code ]:
2910900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2910900090
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
Mutat. Res. 102(2) , 193-200, (1982)
Unscheduled DNA synthesis (UDS) was examined in normal human peripheral blood lymphocytes (HPBL) exposed to n- and tert.-butyl glycidyl ethers (BGE). n-BGE, which is currently used as a major reactive...
Purification and characterisation of a novel enantioselective epoxide hydrolase from Aspergillus niger M200.Biochim. Biophys. Acta 1760(2) , 245-252, (2006)
Purification of a novel enantioselective epoxide hydrolase from Aspergillus niger M200 has been achieved using ammonium sulphate precipitation, ionic exchange, hydrophobic interaction, and size-exclus...