CC 1014

Names

[ Name ]:
CC 1014

Biological Activity

[Description]:

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.

[2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.

[3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

Chemical & Physical Properties

[ Density]:
1.116g/cm3

[ Boiling Point ]:
1408ºC at 760 mmHg

[ Molecular Formula ]:
C₆₂H₁₁₁N₁₁O₁₃

[ Molecular Weight ]:
1218.61000

[ Flash Point ]:
805.3ºC

[ Exact Mass ]:
1217.84000

[ PSA ]:
342.98000

[ LogP ]:
5.73340

[ Index of Refraction ]:
1.515

Precursor & DownStream

Precursor

DownStream

Related Compounds

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