dimethylmaleic anhydride
Names
[ CAS No. ]:
766-39-2
[ Name ]:
dimethylmaleic anhydride
[Synonym ]:
3,4-dimethylmaleic acid anhydride
1-ethoxy-2-methyl-1-methylselanyl-propene
Dimethylketol
3,4-Dimethyl-2,5-furandione
dimethylmaleic anhydride
2,2'-dimethylmaleic anhydride
3-hydroxy-2-oxobutane
2,5-Furandione, 3,4-dimethyl-
2,3-dimethyl maleic anhydride
pyrocinchonic anhydride
2-hydroxybutan-3-one
3,4-dimethylfuran-2,5-dione
EINECS 212-165-8
dimethylketene O-ethyl Se-methyl selenoacetal
acetylmethylcarbino
acetyl methyl carbinol
2,3-Dimethylmaleic anhydride
MFCD00005523
2,3-dimethylfumaric anhydride
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
223.0±0.0 °C at 760 mmHg
[ Melting Point ]:
93-96 °C(lit.)
[ Molecular Formula ]:
C6H6O3
[ Molecular Weight ]:
126.110
[ Flash Point ]:
95.6±15.9 °C
[ Exact Mass ]:
126.031693
[ PSA ]:
43.37000
[ LogP ]:
0.82
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.487
[ Storage condition ]:
0-6°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ON4025000
- CHEMICAL NAME :
- Maleic anhydride, dimethyl-
- CAS REGISTRY NUMBER :
- 766-39-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H6-O3
- MOLECULAR WEIGHT :
- 126.12
- WISWESSER LINE NOTATION :
- T5VOVJ D1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2600 mg/kg/65W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 19,392,1965
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S45-S36/37/39-S28A-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
ON4025000
[ HS Code ]:
2917190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2917190090
[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Int. J. Pharm. 471(1-2) , 127-34, (2014)
In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity onc...
Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.Int. J. Pharm. 471(1-2) , 166-72, (2014)
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a...
A smart polymeric platform for multistage nucleus-targeted anticancer drug delivery.Biomaterials 65 , 43-55, (2015)
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. Here we report a smart polymeric ...