Dehydronuciferine

Names

[ Name ]:
Dehydronuciferine

[Synonym ]:
1,2-Dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline
4H-Dibenzo[de,g]quinoline, 5,6-dihydro-1,2-dimethoxy-6-methyl-

Biological Activity

[Description]:

Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 25 μg/mL (AChE)[1]

[References]

[1]. Yang, et al. Synthesis and structure-activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors. Medicinal Chemistry Research June 2014, Volume 23, Issue 6, pp 3178–3186

Chemical & Physical Properties

[ Density]:
1.193±0.06 g/cm3

[ Boiling Point ]:
493.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₉NO₂

[ Molecular Weight ]:
293.360

[ Flash Point ]:
190.9±17.3 °C

[ Exact Mass ]:
293.141571

[ LogP ]:
4.37

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.664

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Insuluble (9.4E-3 g/L) (25 ºC)

Related Compounds

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