Ethane,2,2-dichloro-1,1-difluoro-1-methoxy-
Names
[ CAS No. ]:
76-38-0
[ Name ]:
Ethane,2,2-dichloro-1,1-difluoro-1-methoxy-
[Synonym ]:
MFCD00040144
2,2-dichloro-1,1-difluoro-1-methoxyethane
EINECS 200-956-0
2,2-Dichloro-1,1-Difluoroethyl Methyl Ether
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.4262
[ Boiling Point ]:
103 °C
[ Melting Point ]:
-36°C
[ Molecular Formula ]:
C3H4Cl2F2O
[ Molecular Weight ]:
164.96600
[ Flash Point ]:
37°C
[ Exact Mass ]:
163.96100
[ PSA ]:
9.23000
[ LogP ]:
2.02930
[ Index of Refraction ]:
1.386
[ Storage condition ]:
-70°C
[ Stability ]:
Stability
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KN7820000
- CHEMICAL NAME :
- Ether, 2,2-dichloro-1,1-difluoroethyl methyl
- CAS REGISTRY NUMBER :
- 76-38-0
- BEILSTEIN REFERENCE NO. :
- 1737766
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 34
- MOLECULAR FORMULA :
- C3-H4-Cl2-F2-O
- MOLECULAR WEIGHT :
- 164.97
- WISWESSER LINE NOTATION :
- GYGXFFO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 3500 ppm/1H
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - renal function tests depressed
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33500 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21500 mg/m3
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 34 gm/m3
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 ppm/24H/14W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48600 mg/m3/4H/30D-I
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 100 ppm/8H
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 400 ppm/8H
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 2 ppm/4H
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 2000 ppm/4H
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Bird - chicken
- REFERENCE :
- ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,366,1976 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 TOXICOLOGY REVIEW ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 16,67,1976 TOXICOLOGY REVIEW KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972- Volume(issue)/page/year: 10,82,1976 TOXICOLOGY REVIEW CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 19,152,1972 TOXICOLOGY REVIEW ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950- Volume(issue)/page/year: 25,411,1974 TOXICOLOGY REVIEW AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 57,328,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 2 ppm (14 mg/m3) JAN 1993 OEL-RUSSIA:STEL 200 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHOXYFLURANE-air:CL 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82904 No. of Facilities: 627 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 8095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82904 No. of Facilities: 2120 (estimated) No. of Industries: 2 No. of Occupations: 14 No. of Employees: 32772 (estimated) No. of Female Employees: 18210 (estimated)
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
S23-S24/25
[ RIDADR ]:
3271
[ RTECS ]:
KN7820000
[ Packaging Group ]:
III
[ Hazard Class ]:
3