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K6PC-5

Names

[ CAS No. ]:
756875-51-1

[ Name ]:
K6PC-5

[Synonym ]:
UNII-9UO46U4GM1
Dihydroxyisopropyl capryloylcaprylamide
K6PC-5

Biological Activity

[Description]:

K6PC-5, a synthetic ceramide derivative,is a direct sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 is used for the researches of skin diseases involving abnormal keratinocyte, neurodegeneration and virus infection[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Neurological Disease
Signaling Pathways >> Immunology/Inflammation >> SPHK

[References]

[1]. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. 

[2]. Di Pardo A, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease. Neurobiol Dis. 2020 Sep;143:105009. 

[3]. Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H37NO4

[ Molecular Weight ]:
343.50100

[ Exact Mass ]:
343.27200

[ PSA ]:
90.12000

[ LogP ]:
3.81230

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds