alpha-Tocopherolquinone

Names

[ Name ]:
alpha-Tocopherolquinone

[Synonym ]:
2-(3-Hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethyl-1,4-benzoquinone
2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethyl-
EINECS 231-450-8

Biological Activity

[Description]:

D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone isolated from Phaeodactylum tricornutum. Tocopherylquinone is an inhibitor of vitamin K[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. K Shimazaki, et al. Studies on electron transfer systems in the marine diatom Phaeodactylum tricornutum. II. Identification and determination of quinones, cytochromes, and flavins. J Biochem. 1978 Jun;83(6):1639-42.

[2]. M K Horwitt. Vitamin E: a reexamination. Am J Clin Nutr. 1976 May;29(5):569-78.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
535.8±29.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₅₀O₃

[ Molecular Weight ]:
446.706

[ Flash Point ]:
291.9±20.8 °C

[ Exact Mass ]:
446.376007

[ PSA ]:
54.37000

[ LogP ]:
10.42

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.486

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK5170000

CHEMICAL NAME :: p-Benzoquinone, 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-tr imethyl-

CAS REGISTRY NUMBER :: 7559-04-8

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H50-O3

MOLECULAR WEIGHT :: 446.79

WISWESSER LINE NOTATION :: L6V DVJ B2XQ1&3Y1&3Y1&3Y1&1 C1 E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 675 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,767,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1980 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,767,1975

Safety Information

[ Safety Phrases ]:
S24/25

[ RTECS ]:
DK5170000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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