Bovine adrenal medulla dodecapeptide

Names

[ Name ]:
Bovine adrenal medulla dodecapeptide

[Synonym ]:
BOVINE ADRENAL MEDULLA-12P
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU
H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-OH
Peptide E(1-12)
BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
BOVINE ANDRENAL MEDULLA DODECAPEPTIDE
YGGFMRRVGRPE
BOVINE ADRENAL MEDULLA DODECAPEPTIDE

Biological Activity

[Description]:

BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Signaling Pathways >> Immunology/Inflammation >> CXCR

Research Areas >> Neurological Disease

[Target]

human κ-opioid receptor (hKOR):101 nM (EC50)

human κ-opioid receptor (hKOR):6.99 (pEC50)

CXCR7:175 nM (EC50)

[In Vitro]

BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性，IC50 为 15.5 nM[2]。

[References]

[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8.

[2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36.

[3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₂H₉₇N₂₁O₁₆S

[ Molecular Weight ]:
1424.63000

[ Exact Mass ]:
1423.71000

[ PSA ]:
643.16000

[ LogP ]:
2.50620

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Substrate specificity of a novel serine protease from soybean [Glycine max (L.) Merrill].

J. Biochem. 119(6) , 1094-9, (1996)

The substrate specificity of a novel serine protease isolated from soybean seeds, cultivar Keburi, was investigated using various peptide-MCAs and several neuropeptides involving single and paired bas...

Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.

Neurosci. Lett. 61(3) , 267-71, (1985)

The inhibitory activity of several pro-enkephalin A-derived opioid peptides, containing the sequence of Met-enkephalin, was evaluated in two isolated organ preparations sensitive to opioids, the guine...

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.

Biochem. Biophys. Res. Commun. 97 , 1283, (1980)

Related Compounds

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