Simpinicline

Names

[ Name ]:
Simpinicline

[Synonym ]:
Pyrimidine, 5-[(E)-2-(3-pyrrolidinyl)ethenyl]-
5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine

Biological Activity

[Description]:

Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

[References]

[1]. Quik M, et al. α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology. 2013 Aug;71:191-203.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₃N₃

[ Molecular Weight ]:
175.23

Related Compounds

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