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monochloroethane

Names

[ CAS No. ]:
75-00-3

[ Name ]:
monochloroethane

[Synonym ]:
ethyl cerotate
Hexacosansaeure-aethylester
monochloroethane
1-CHLORO-ETHANE
hydrochloric ether
Ethane, chloro-
Ethylhexacosanoat
Chloroethane
ethyl chloride
1-ethyl chloride
mono-chloroethane
hexacosanoic acid ethyl ester
MFCD00000961
ETHYL HEXACOSANATE
EINECS 200-830-5

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
12.7±3.0 °C at 760 mmHg

[ Melting Point ]:
−139 °C(lit.)

[ Molecular Formula ]:
C2H5Cl

[ Molecular Weight ]:
64.514

[ Flash Point ]:
-56.7±2.8 °C

[ Exact Mass ]:
64.007980

[ LogP ]:
1.50

[ Vapour density ]:
2.22 (vs air)

[ Vapour Pressure ]:
1169.9±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.362

[ Stability ]:
Stable. Highly flammable - may form explosive mixtures with air. Incompatible with strong oxidizing agents, alkali metals and their alloys.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH7525000
CHEMICAL NAME :
Ethane, chloro-
CAS REGISTRY NUMBER :
75-00-3
LAST UPDATED :
199712
DATA ITEMS CITED :
56
MOLECULAR FORMULA :
C2-H5-Cl
MOLECULAR WEIGHT :
64.52
WISWESSER LINE NOTATION :
G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
152 gm/m3/2H
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - general anesthetic Blood - hemorrhage
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
146 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
40000 ppm/45M
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
19000 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 gm/m3/2H/60D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Immunological Including Allergic - decrease in cellular immune response
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/m3/4H/26W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Immunological Including Allergic - decrease in cellular immune response Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/23H/11D-I
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19000 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15000 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15000 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - uterine tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
60 mg/m3/4H
SEX/DURATION :
male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 322,33,1994 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 264 mg/m3 (100 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,315,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,315,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,315,1991 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (2600 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,106,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (2600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (2600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (2600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (2600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1000 ppm (2640 mg/m3) JAN 1993 OEL-DENMARK:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-FINLAND:TWA 500 ppm (1300 mg/m3);STEL 625 ppm (1625 mg/m3) JAN 1993 OEL-FRANCE:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-GERMANY:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 300 mg/m3 JAN 1993 OEL-JAPAN:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 1000 ppm;STEL 50 mg/m3 JAN 1993 OEL-SWEDEN:TWA 500 ppm (1300 mg/m3);STEL 700 ppm (1900 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (2600 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (2600 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MONOCHLOROETHANE-air:Handle with caution REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 31970 No. of Facilities: 6154 (estimated) No. of Industries: 80 No. of Occupations: 66 No. of Employees: 96531 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 31970 No. of Facilities: 766 (estimated) No. of Industries: 12 No. of Occupations: 47 No. of Employees: 49210 (estimated) No. of Female Employees: 35368 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315-H351

[ Supplemental HS ]:
May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.

[ Precautionary Statements ]:
P210-P281

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F+:Extremelyflammable;Xn:Harmful;

[ Risk Phrases ]:
R12;R40;R52/53

[ Safety Phrases ]:
S9-S16-S33-S36/37-S61-S45-S7-S29-S36/37/39-S26-S53

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
KH7525000

[ Hazard Class ]:
2.1

[ HS Code ]:
2903110000

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2903110000

[ Summary ]:
2903110000 chloroethane。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

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