NSC 405020

Names

[ Name ]:
NSC 405020

[Synonym ]:
3,4-Dichloro-N-(2-pentanyl)benzamide
Benzamide, 3,4-dichloro-N-(1-methylbutyl)-
NSC 405020

Biological Activity

[Description]:

NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2. IC50 value: > 100 uM [1]Target: MT1-MMP PEX inhibitorNSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I.

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Remacle AG, et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012 May 1;72(9):2339-49.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
353.7±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₅Cl₂NO

[ Molecular Weight ]:
260.160

[ Flash Point ]:
167.7±25.1 °C

[ Exact Mass ]:
259.053070

[ PSA ]:
29.10000

[ LogP ]:
4.29

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.532

[ Storage condition ]:
room temp

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26-24/25

[ RIDADR ]:
3077

Related Compounds

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