Triptophenolide

Names

[ Name ]:
Triptophenolide

[Synonym ]:
Triptophenolide
Phenanthro[1,2-c]furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR,9bS)-
6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one
(3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one

Biological Activity

[Description]:

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:

[Related Catalog]:

Signaling Pathways >> Others >> Androgen Receptor

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

[References]

[1]. XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04

[2]. Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

[Related Small Molecules]

ARN-509 | Dehydroepiandrosterone | Flutamide | ODM-201 | Danazol | 3,3'-Diindolylmethane | AZD3514 | RAD140 | BMS-564929 | GLPG0492 | Cyproterone acetate | LGD-4033 | Lupeol | Andarine | MK-0773

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
490.0±45.0 °C at 760 mmHg

[ Melting Point ]:
232-233ºC

[ Molecular Formula ]:
C₂₀H₂₄O₃

[ Molecular Weight ]:
312.403

[ Flash Point ]:
202.4±21.5 °C

[ Exact Mass ]:
312.172546

[ PSA ]:
46.53000

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.603

[ Storage condition ]:
-20°C

Safety Information

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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