H-Tic-OH

Names

[ Name ]:
H-Tic-OH

[Synonym ]:
(3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid
3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, (3S)-
(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
MFCD00800357
H-Tic-OH
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Biological Activity

[Description]:

L-Porretine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

一种抗酶促降解的受限苯丙氨酸类似物。

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
372.0±42.0 °C at 760 mmHg

[ Melting Point ]:
300ºC

[ Molecular Formula ]:
C₁₀H₁₁NO₂

[ Molecular Weight ]:
177.20

[ Flash Point ]:
178.8±27.9 °C

[ Exact Mass ]:
177.078979

[ PSA ]:
49.33000

[ LogP ]:
0.86

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.

Int. J. Pept. Protein Res. 45(6) , 567-73, (1995)

The kinetics of the spontaneous formation of 2,5-dioxopiperazines from peptides containing the Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) residue in the 2-position of the sequence has been...

2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation.

Bioorg. Med. Chem. 19 , 871-82, (2011)

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (TIC) can inhibit thrombosis by inhibiting platelet aggregation. The investigation of amino acids modified TIC reveals that a stretching conformati...

Constrained phenylalanine analogues. Preferred conformation of the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) residue.

Int. J. Pept. Protein Res. 40 , 222, (1992)

Three Tic-containing (Tic = 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) model peptides were synthesized to assess the tendency of this constrained Phe analogue to fold into a beta-bend and a hel...