β-Casomorphin (1-4) amide (bovine) acetate salt

Names

[ Name ]:
β-Casomorphin (1-4) amide (bovine) acetate salt

[Synonym ]:
Morphiceptin, Beta-Casomorphin (1-4) amide (bovine)
B-CASOMORPHIN (1-4) AMIDE (BOVINE)
cis-Morphiceptin
Beta-Casomorphin (1-4) amide (bovine).Morphiceptin
trans-Morphiceptin
morphicetin
morphiceptin
N-((R)-α-methylbenzyl)-3-aminopropan-1-ol

Biological Activity

[Description]:

Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Morphine (μ) Receptor[1]

[In Vivo]

Morphiceptin potently inhibits the binding of [3H]dihydromorphine, 125I-labeled FK33824, and [3H]naloxone to rat brain membrane preparations with a 50 percent inhibition concentration (IC50) of about 20 nM[1].

[References]

[1]. Chang KJ, et al. Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors. Science. 1981;212(4490):75-77.

Chemical & Physical Properties

[ Density]:
1.327±0.06 g/cm3(Predicted)

[ Boiling Point ]:
919.9±65.0 °C(Predicted)

[ Molecular Formula ]:
C₂₈H₃₅N₅O₅

[ Molecular Weight ]:
521.60800

[ Exact Mass ]:
521.26400

[ PSA ]:
159.06000

[ LogP ]:
2.12410

Related Compounds

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