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(-)-Bicuculline methobromide

Names

[ CAS No. ]:
73604-30-5

[ Name ]:
(-)-Bicuculline methobromide

[Synonym ]:
Guvacine hydrochloride
MFCD00055149

Biological Activity

[Description]:

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABAA[1]


[In Vivo]

(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2]. Animal Model: Rat L5-SNL model[2] Dosage: 0.6 nmol/rat Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) Result: Attenuated the antiallodynic effect of Neurotropin.

[References]

[1]. Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70.

[2]. Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20BrNO6

[ Molecular Weight ]:
462.29100

[ Exact Mass ]:
461.04700

[ PSA ]:
63.22000

Safety Information

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN 1544 6.1/PG 2

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds